Lawesson's reagent → HCID 68911731, compound

Participants

Reaction Steps

Lawesson's reagent (213 mg, 0.53 mmol) was added to a solution of the acetyl acetohydrazide of step (b) of Example 140 (170 mg, 0.48 mmol) in tetrahydrofuran (10 ml) and the reaction mixture was stirred at room temperature for 18 hours. It was then evaporated to dryness and purified by flash chromatography on silica gel eluting with ethyl acetate:pentane (1:1 then 2:1, by volume) to provide the title compound (80 mg, 47%).

Provenance & Evidence