Oxalyl chloride → 2-(Dimethylamino)benzoyl chloride

Participants

Reaction Steps

Oxalyl chloride (375 g) was added to a suspension prepared by adding 3.0 L of dry methylene chloride to 371.7 g of N,N-dimethylaminobenzoic acid. A vessel containing the resultant solution was dipped in an oil bath, and the solution was stirred for 3 hr while controlling the internal temperature at about 40° C. The solvent was removed by evaporation under the reduced pressure, and the residue was vacuum dried to give a crude product of N,N-dimethylaminobenzoic acid chloride.

Provenance & Evidence