Nitric Acid → HCID 12010428, compound

HRID 1455492Notes

Reaction equation

HRID 1455492 reaction equation
[N+]([O-])(O)=O.[Cl:5][C:6]1[C:7]([F:16])=[C:8]([CH:12]=[CH:13][C:14]=1[F:15])[C:9]([OH:11])=[O:10].[Br:17]Br>C(O)(=O)C.O.[N+]([O-])([O-])=O.[Ag+]>[Br:17][C:13]1[C:14]([F:15])=[C:6]([Cl:5])[C:7]([F:16])=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10]

Participants

7

Reactant 3

HCID 944Nitric AcidHCID 24408BromineHCID 27735323-Chloro-2,4-difluorobenzoic acid

Product 1

HCID 12010428HCID 12010428, compound

Reagents, catalysts & solvents 3

HCID 24470Silver NitrateCatalystHCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Procedure

In a mixture of 50 ml of acetic acid, 10 ml of water and 13 ml of nitric acid is dissolved 2 g (0.014 mole) of 3-chloro-2,4-difluorobenzoic acid and 3.64 ml (0.028 mole) of bromine. A solution of 3.52 g (0.0208 mole) of silver nitrate in 10 ml of water is then added slowly. After 14 hours at 20° C., the precipitate is filtered and rinsed with ether. The organic phase is washed with sodium bisulfite, then water and dried. Removal of the solvent affords the desired product.

Workup

  1. filtrationthe precipitate is filtered
  2. washrinsed with ether
  3. washThe organic phase is washed with sodium bisulfite
  4. dry with materialwater and dried
  5. customRemoval of the solvent

Sources & evidence

ORD record
ord-8a7bc26a3ffa406aace740ae545ca69c
Source dataset
uspto-grants-2009_01
Patent number
US07482454B2

Reaction notes

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