HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1455495Generated: October 31, 2026
Acetic Acid → 1-Cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
https://huagongshe.com/reaction/1455495
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ethyl 1-cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 10402814 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 22662081 | — |
Reaction Steps
A quantity of 28.6 g of ethyl-1-cyclopropyl-1,4-dihydro-7-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylate and 300 mL of a mixture of acetic acid, water, sulfuric acid (8/6/1) are refluxed for 2 hours. The reaction mixture is cooled at 0° C. and the desired product collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07482454B2 |
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| Source dataset | uspto-grants-2009_01 |
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| ORD ID | ord-3dda8c10d9db41ba84e7821ccd6d05e5 |
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| Source note | uspto-grants-2009_01 |
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