Potassium Carbonate → HCID 10407118, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-Chloro-7-methoxy-quinoline-3-carboxylic acid (60 mg, 0.22 mmol), (3-Amino-propyl)-carbamic acid tert-butyl ester (77 mg, 0.44 mmol), Potassium carbonate (73 mg, 0.46 mmol), and Molecular sieve-4A (300 mg) in dry DMSO (4 ml) was heated at 100° C. for over night. The reaction mixture was purified by chromatography on SCX column using MeOH as eluent and 2-(3-tert-Butoxycarbonylamino-propylamino)-7-methoxy-quinoline-3-carboxylic acid was obtained as white solid after recrystallization from CH2Cl2 and Hexane; 70 mg (85%).

Provenance & Evidence