反应详情

A mixture of Example 1 (0.5 g) and Intermediate 2 (0.35 g) in MeCN (10 mL) was heated at reflux for 1.5 h. H2O (2.5 mL) was added and the resulting mixture was concentrated in vacuo. The resulting solid precipitate was recovered by filtration and dried under vacuum to give 6-oxo-2-[2-oxo-2-(pyrrolidin-1-yl)ethylsulfanyl]-1-phenyl-1,6-dihydropyridine-3-carbonitrile (0.56 g). δH (DMSO-d6) 7.998 (1H, d, J 9.5 Hz), 7.75 (3H, m), 7.55 (2H, m), 6.85 (1H, d, J 9.5 Hz), 3.86 (2H, s), 3.62-3.37 (4H, m), 2.15-1.90 (4H, m). A mixture of this material (0.38 g) and K2CO3 (0.31 g) in EtOH (7.5 mL) was heated at reflux for 2.5 h. H2O (10 mL) was added and the mixture was concentrated under vacuum. The resulting solid product was filtered, washed with water and dried in vacuo to give the title compound as an off-white solid (0.37 g). δH (DMSO-d6) 8.12 (1H, d, J 9.4 Hz), 7.66-7.50 (3H, m), 7.44 (2H, m), 7.25 (2H, br s), 6.50 (1H, d, J 9.4 Hz), 3.36 (4H, m), 1.75 (4H, m). LCMS (ES+) RT 2.84 minutes, 340 (M+H)+.

1. temperatureat reflux for 1.5 h
2. concentrationthe resulting mixture was concentrated in vacuo
3. filtrationThe resulting solid precipitate was recovered by filtration
4. customdried under vacuum