反应详情

Esomeprazole magnesium trihydrate (20 g) was dissolved in methanol (200 ml) at 25-30° C. Any undissolved material was filtered off and triethylamine (0.2 ml) was added to the filtrate. The clear solution thus obtained was subjected to spray drying with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C. The solid was further dried under vacuum at 60-65° C. for 14 to 15 hours to yield 11.5 g of esomeprazole magnesium of amorphous form.

1. filtrationAny undissolved material was filtered off
2. additiontriethylamine (0.2 ml) was added to the filtrate
3. customThe clear solution thus obtained
4. customto spray drying with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C
5. customThe solid was further dried under vacuum at 60-65° C. for 14 to 15 hours