Esomeprazolemagnesiumtrihydrate → HCID 178488035, compound

HRID 1455535Notes

Reaction equation

HRID 1455535 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH3:10])[C:5]([CH2:11][S:12]([C:14]2[N-:18][C:17]3[CH:19]=[CH:20][C:21]([O:23][CH3:24])=[CH:22][C:16]=3[N:15]=2)=[O:13])=[N:4][CH:3]=1.[CH3:25][C:26]1[C:31]([O:32][CH3:33])=[C:30]([CH3:34])[C:29]([CH2:35][S:36]([C:38]2[N-:42][C:41]3[CH:43]=[CH:44][C:45]([O:47][CH3:48])=[CH:46][C:40]=3[N:39]=2)=[O:37])=[N:28][CH:27]=1.O.O.O.[Mg+2:52]>CO>[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:13])[C:14]2[N-:18][C:17]3[CH:19]=[CH:20][C:21]([O:23][CH3:24])=[CH:22][C:16]=3[N:15]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[CH3:25][C:26]1[CH:27]=[N:28][C:29]([CH2:35][S+:36]([O-:37])[C:38]2[N-:42][C:41]3[CH:43]=[CH:44][C:45]([O:47][CH3:48])=[CH:46][C:40]=3[N:39]=2)=[C:30]([CH3:34])[C:31]=1[O:32][CH3:33].[Mg+2:52]

Participants

3

Reactant 1

HCID 130565Esomeprazolemagnesiumtrihydrate

Product 1

HCID 178488035HCID 178488035, compoundYield 61.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Esomeprazole magnesium trihydrate (20 g) was dissolved in methanol (200 ml) at 25-30° C. Any undissolved material was filtered off and triethylamine (0.2 ml) was added to the filtrate. The clear solution thus obtained was subjected to spray drying with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C. The solid was further dried under vacuum at 60-65° C. for 14 to 15 hours to yield 11.5 g of esomeprazole magnesium of amorphous form.

Workup

  1. filtrationAny undissolved material was filtered off
  2. additiontriethylamine (0.2 ml) was added to the filtrate
  3. customThe clear solution thus obtained
  4. customto spray drying with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C
  5. customThe solid was further dried under vacuum at 60-65° C. for 14 to 15 hours

Sources & evidence

ORD record
ord-eb474ed2c03e496688f0c883131842f6
Source dataset
uspto-grants-2009_01
Patent number
US07482463B2

Reaction notes

Loading…