Esomeprazolemagnesiumtrihydrate → HCID 178488035, compound

HRID 1455537Notes

Reaction equation

HRID 1455537 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH3:10])[C:5]([CH2:11][S:12]([C:14]2[N-:18][C:17]3[CH:19]=[CH:20][C:21]([O:23][CH3:24])=[CH:22][C:16]=3[N:15]=2)=[O:13])=[N:4][CH:3]=1.[CH3:25][C:26]1[C:31]([O:32][CH3:33])=[C:30]([CH3:34])[C:29]([CH2:35][S:36]([C:38]2[N-:42][C:41]3[CH:43]=[CH:44][C:45]([O:47][CH3:48])=[CH:46][C:40]=3[N:39]=2)=[O:37])=[N:28][CH:27]=1.O.O.O.[Mg+2:52]>CO>[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:13])[C:14]2[N-:18][C:17]3[CH:19]=[CH:20][C:21]([O:23][CH3:24])=[CH:22][C:16]=3[N:15]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[CH3:25][C:26]1[CH:27]=[N:28][C:29]([CH2:35][S+:36]([O-:37])[C:38]2[N-:42][C:41]3[CH:43]=[CH:44][C:45]([O:47][CH3:48])=[CH:46][C:40]=3[N:39]=2)=[C:30]([CH3:34])[C:31]=1[O:32][CH3:33].[Mg+2:52]

Participants

3

Reactant 1

HCID 130565Esomeprazolemagnesiumtrihydrate

Product 1

HCID 178488035HCID 178488035, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Esomeprazole magnesium trihydrate (100 g) was dissolved in methanol (1000 ml) at 25-30° C. Any undissolved material was filtered off. The clear solution thus obtained was spray dried with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C. The solid was further dried under vacuum at 60-65° C. for 14 to 15 hours to yield 55g of esomeprazole magnesium of amorphous form.

Workup

  1. filtrationAny undissolved material was filtered off
  2. customThe clear solution thus obtained
  3. customdried with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C
  4. customThe solid was further dried under vacuum at 60-65° C. for 14 to 15 hours

Sources & evidence

ORD record
ord-045e8a07af0648a9aa2d65d65bbff130
Source dataset
uspto-grants-2009_01
Patent number
US07482463B2

Reaction notes

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