HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Bromo-2,5-dichloro-thiophene-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-bromo-2,5-dichlorothiophene-3-sulfonyl chloride | HCID 519295 | — |
| Product | 4-Bromo-2,5-dichloro-thiophene-3-sulfonamide | HCID 2740318 | — |
Reaction Steps
90 ml of an aqueous solution of NH3 (32%) is added at RT to a solution of 8.88 g of 4-bromo-2,5-dichloro-thiophene-3-sulfonylchloride in 120 ml of EtAc. The mixture obtained is stirred for ca. 15 h and two phases obtained are separated. The organic layer is washed with 1 N HCl and H2O, and dried. Solvent of the organic solution obtained is evaporated. 4-Bromo-2,5-dichloro-thiophene-3-sulfonamide in the form of a white powder is obtained. m.p. 113-117° C., 13C-NMR: δ=108.287; 125.342; 130.404; 135.716.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482462B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-99f05136f0dc4da7a781cfcb54293749 |
| Source note | uspto-grants-2009_01 |