Ammonia → 3,5-bis(trifluoromethyl)benzenesulfonamide

HRID 1455549Notes

Reaction equation

HRID 1455549 reaction equation
[NH3:1].[F:2][C:3]([F:19])([F:18])[C:4]1[CH:5]=[C:6]([S:14](Cl)(=[O:16])=[O:15])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1>>[F:2][C:3]([F:19])([F:18])[C:4]1[CH:5]=[C:6]([S:14]([NH2:1])(=[O:16])=[O:15])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 5209453,5-Bis(trifluoromethyl)benzenesulphonyl chloride

Product 1

HCID 27831653,5-bis(trifluoromethyl)benzenesulfonamide

Procedure

An aqueous solution of NH3 (32%) is added at RT to a solution of 3,5-bis(trifluoromethyl)-benzene-sulfonylchloride in EtAc. The mixture obtained is stirred and two phases are obtained and are separated. The organic layer obtained is washed with 1 N HCl and H2O, and dried. Solvent of the organic solution obtained is evaporated. 3,5-Bis-trifluoromethyl-benzene sulfonamide is obtained.

Workup

  1. customThe mixture obtained
  2. customtwo phases are obtained
  3. customare separated
  4. customThe organic layer obtained
  5. washis washed with 1 N HCl and H2O
  6. customdried
  7. customSolvent of the organic solution obtained
  8. customis evaporated

Sources & evidence

ORD record
ord-6d28d405d9654a239eb4e5f58fc183fc
Source dataset
uspto-grants-2009_01
Patent number
US07482462B2

Reaction notes

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