4-Bromo-2,5-dichloro-thiophene-3-sulfonamide → HCID 68442783, compound

HRID 1455560Notes

Reaction equation

HRID 1455560 reaction equation
[C:1]([C:4]([F:23])=[C:5]1[CH:12]2[CH2:13][C:8]3([O:15][C:16](=[O:22])[CH2:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:9][CH:10]([CH2:14][CH:6]1[CH2:7]3)[CH2:11]2)(O)=[O:2].[Br:24][C:25]1[C:26]([S:32]([NH2:35])(=[O:34])=[O:33])=[C:27]([Cl:31])[S:28][C:29]=1[Cl:30]>>[Br:24][C:25]1[C:26]([S:32]([NH:35][C:1](=[O:2])[C:4](=[C:5]2[CH:12]3[CH2:13][C:8]4([O:15][C:16](=[O:22])[CH2:17][C:18]([CH3:19])([CH3:21])[CH3:20])[CH2:9][CH:10]([CH2:14][CH:6]2[CH2:7]4)[CH2:11]3)[F:23])(=[O:33])=[O:34])=[C:27]([Cl:31])[S:28][C:29]=1[Cl:30]

Participants

3

Reactant 2

HCID 27403184-Bromo-2,5-dichloro-thiophene-3-sulfonamideHCID 57429711HCID 57429711, compound

Product 1

HCID 68442783HCID 68442783, compound

Procedure

Coupling of 3,3-dimethyl-butyric acid 4-(carboxy-fluoro-methylene)-adamantan-1-yl ester with 4-bromo-2,5-dichloro-thiophene-3-sulfonamide and isolation is performed analogously to the method as described in Example K c. 3,3-Dimethyl-butyric acid 4-[2-(4-bromo-2,5-dichloro-thiophene-3-sulfonylamino)-1-fluoro-2-oxo-ethylidene]-adamantan-1-yl ester is obtained.

Sources & evidence

ORD record
ord-875a297df69343aca538605a7e6caa6a
Source dataset
uspto-grants-2009_01
Patent number
US07482462B2

Reaction notes

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