HCID 86625019, compound → HCID 86625018, compound

HRID 1455566Notes

Reaction equation

HRID 1455566 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][S:15](=[O:34])(=[O:33])[NH:16][C:17](=[O:32])[C:18]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[C:20]([C:28]([F:31])([F:30])[F:29])[CH:19]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][S:15](=[O:33])(=[O:34])[NH:16][C:17](=[O:32])[C:18]2[CH:23]=[C:22]([C:24]([F:25])([F:26])[F:27])[CH:21]=[C:20]([C:28]([F:29])([F:30])[F:31])[CH:19]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 86625019HCID 86625019, compound

Product 1

HCID 86625018HCID 86625018, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 880 mg of 4-[(3,5-bis-trifluoromethyl-benzoylsulfamoyl)-methylene]-piperidine-1carboxylic acid tert.-butyl ester in 100 ml of MeOH is hydrogenated (10% Pd/C as a catalyst). From the mixture obtained the catalyst is filtrated off and solvent is evaporated.

Workup

  1. customFrom the mixture obtained the catalyst
  2. filtrationis filtrated off
  3. customsolvent is evaporated

Sources & evidence

ORD record
ord-544c91611257402e9fc05be7409aacb7
Source dataset
uspto-grants-2009_01
Patent number
US07482462B2

Reaction notes

Loading…