Hydrochloric Acid → (S)-2-Amino-1-(5-thiophen-2-yl-oxazol-2-yl)-butan-1-ol hydrochloride

Participants

Reaction Steps

To a solution of {(S)-1-[hydroxy-(5-thiophen-2-yl-oxazol-2-yl)-methyl]-propyl}-carbamic acid tert-butyl ester (361 mg, 1.07 mmol) in dry dichloromethane (3 mL) is added 4N HCl in dioxane (3.0 mL, XS). The mixture is stirred at room temperature for 16 h, then concentrated in vacuum to afford (S)-2-Amino-1-(5-thiophen-2-yl-oxazol-2-yl)-butan-1-ol hydrochloride as a solid (quant.).

Provenance & Evidence