HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 68822405, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {1-[(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-hydroxy-methyl]-propyl}-carbamic acid tert-butyl ester | HCID 68822601 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68822405 | HCID 68822405 | — |
Reaction Steps
A mixture of {1-[(5-cyclopropyl-[1,3,4]oxadiazol-2-yl)-hydroxy-methyl]-propyl}-carbamic acid tert-butyl ester (2.83 g, 9.95 mmol), trifluoro acetic acid (5 mL) in dichloromethane (20 mL) is stirred at room temperature for 2 hrs and concentrated to dryness under reduced pressure to give (S)-2-amino-1-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-butan-1-ol: compound with trifluoro-acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482448B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-83263ca7d82446d986ed9c4baa2e3e93 |
| Source note | uspto-grants-2009_01 |