(S)-4,4-Difluoro-2-[(morpholine-4-carbonyl)-amino]-5-phenyl-pentanoic acid → Morpholine-4-carboxylic acid {1-[1-(5-cyclopropyl-[1,3,4]oxadiazole-2-carbonyl)-propylcarbamoyl]-3,3-difluoro-phenyl-butyl}-amide

Participants

Reaction Steps

By proceeding in a similar manner to Example 1 above but using (S)-4,4-difluoro-2-[(morpholine-4-carbonyl)-amino]-5-phenyl-pentanoic acid and (S)-2-amino-1-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-butan-1-ol Trifluoro acetic acid salt, there is prepared morpholine-4-carboxylic acid {1-[1-(5-cyclopropyl-[1,3,4]oxadiazole-2-carbonyl)-propylcarbamoyl]-3,3-difluoro-4-phenyl-butyl}-amide.

Provenance & Evidence