HCID 68821240, compound → HCID 11211042, compound

HRID 1455608Notes

Reaction equation

HRID 1455608 reaction equation
[F:1][C:2]([F:21])([CH2:18][CH2:19][CH3:20])[CH2:3][CH:4]([NH:8][C:9]([N:11]1[CH2:17][CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])[C:5]([OH:7])=O.Cl.[NH2:23][C@@H:24]([CH2:27][CH3:28])[C:25]#[N:26]>>[C:25]([C@@H:24]([NH:23][C:5]([C@@H:4]([NH:8][C:9]([N:11]1[CH2:17][CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])[CH2:3][C:2]([F:1])([F:21])[CH2:18][CH2:19][CH3:20])=[O:7])[CH2:27][CH3:28])#[N:26]

Participants

3

Reactant 2

HCID 68821240HCID 68821240, compoundHCID 75481259(S)-2-aminobutanenitrile hydrochloride

Product 1

HCID 11211042HCID 11211042, compound

Procedure

By proceeding in a similar manner to Example 28 above but using 4,4-Difluoro-2-[([1,4]oxazepane-4-carbonyl)-amino]-heptanoic acid and (S)-2-Amino-butyronitrile hydrochloride there is prepared Perhydro-1,4-oxazepine4-carboxylic acid [(S)-1-((S)-1-cyano-propylcarbamoyl)-3,3-fluoro-hexyl]-amide.

Sources & evidence

ORD record
ord-17a2ad9df856409a8155211042629bfb
Source dataset
uspto-grants-2009_01
Patent number
US07482448B2

Reaction notes

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