HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → Morpholine-4-carboxylic acid [(S)-1-(1-cyano-cyclopropylcarbamoyl)-3,3-difluoro-hexyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Reactant | 1-Amino-1-cyclopropanecarbonitrile hydrochloride | HCID 14586363 | — |
| Reactant | (S)-4,4-difluoro-2-[(morpholine-4-carbonyl)-amino]-heptanoic acid | HCID 57535361 | — |
| Product | Morpholine-4-carboxylic acid [(S)-1-(1-cyano-cyclopropylcarbamoyl)-3,3-difluoro-hexyl]-amide | HCID 11485129 | — |
Reaction Steps
Prepared by reacting (S)-4,4-Difluoro-2-[(morpholine-4-carbonyl)-amino]-heptanoic acid and 1-Amino-cyclopropanecarbonitrile hydrochloride, using TOTU as the coupling agent and diisopropyl ethylamine as the base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482448B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-8246fdcf3a854ffd844bfed8f2f7295a |
| Source note | uspto-grants-2009_01 |