Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | HCID 68960107 | HCID 68960107 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Acetic acid methylene chloride | HCID 21922555 | — |
| Product | HCID 57535432 | HCID 57535432 | — |
Reaction Steps
To a solution of 3-amino-2-[4-(methylsulfonyl)phenyl]pyridine (1.0 eq.) in AcOH:CH2Cl2 (1:1, 0.13 M) at −20° C. was added I2 (1.5 eq), KI (1.5 eq) then NaNO2(1.5 eq). The mixture was stirred at 20° C. for 2 h then diluted with EtOAc and water. The organic extracts were washed with aqueous NaHCO3, brine, dried over MgSO4, filtered and concentrated. Flash chromatography (Hex:EtOAc; 40:60) afforded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07482456B2 |
|---|
| Source dataset | uspto-grants-2009_01 |
|---|
| ORD ID | ord-08616e09b8fc4d4ea5e35e3b6622eb09 |
|---|
| Source note | uspto-grants-2009_01 |
|---|
