HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1455636Generated: November 2, 2026
N-Hydroxyacetamidine → 2-Chloro-3-(3-methyl-1,2,4-oxadiazol-5-yl)pyridine
https://huagongshe.com/reaction/1455636
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-Hydroxyacetamidine | HCID 30926 | — |
| Reactant | 2-Chloronicotinoyl chloride | HCID 2774541 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Chloro-3-(3-methyl-1,2,4-oxadiazol-5-yl)pyridine | HCID 8027205 | — |
Reaction Steps
A mixture of 2-chloro nicotinoyl chloride (1.0 eq.) and N′-hydroxy ethanimidamide (1.1 eq) in pyridine (0.6 M) was stirred at 100° C. for 4 h and then concentrated. The residue was purified by flash chromatography (Hexane:EtOAc, 70:30) to afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07482456B2 |
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| Source dataset | uspto-grants-2009_01 |
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| ORD ID | ord-6f63b64901eb4630b0d7e7d433e36c45 |
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| Source note | uspto-grants-2009_01 |
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