Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-3-(3-methyl-1,2,4-oxadiazol-5-yl)pyridine | HCID 8027205 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68957422 | HCID 68957422 | — |
Reaction Steps
To a solution of benzyl alcohol (1.5 eq) in DMF (0.4M) was added NaH (1.5 eq, 60%) followed by 2-chloro-3-(3-methyl-1,2,4-oxadiazol-5-yl)pyridine (1 eq) in DMF (0.5M) after 30 min.). The reaction was stirred at 20° C. for 1 h, diluted with Et2O and water. The organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. Flash chromatography (Hex:EtOAc; 80:20) afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07482456B2 |
|---|
| Source dataset | uspto-grants-2009_01 |
|---|
| ORD ID | ord-46a2a531b575456e90db0d2c2b29cfe1 |
|---|
| Source note | uspto-grants-2009_01 |
|---|
