Benzenecarbothioamide, 3-chloro- → HCID 11354397, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the alpha-bromoketone from step 4 (1.0 eq) in DMF (0.1M) was added 3-chlorobenzenecarbothioamide (1.0 eq). The mixture was heated at 40-120° C. for 1-3 h, cooled, diluted with water, saturated NaHCO3 solution and ether. The organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified by flash chromatography (Hexane:EtOAc) to afforded the title compound.

Provenance & Evidence