Dichloromethane → HCID 68957996, compound

HRID 1455654Notes

Reaction equation

HRID 1455654 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Mg]Br)=[CH:4][CH:3]=1.[CH3:10][C:11]([C:17]1[CH:18]=[C:19]2[C:24](=[C:25]([C:27]3[CH:28]=[C:29]([C:33]4[N:34]=[C:35]([C:46](=[O:48])[CH3:47])[S:36][C:37]=4[C:38]4[CH:43]=[CH:42][C:41]([S:44][CH3:45])=[CH:40][CH:39]=4)[CH:30]=[CH:31][CH:32]=3)[CH:26]=1)[N:23]=[CH:22][CH:21]=[CH:20]2)([S:13]([CH3:16])(=[O:15])=[O:14])[CH3:12].C(Cl)Cl>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:46]([C:35]2[S:36][C:37]([C:38]3[CH:43]=[CH:42][C:41]([S:44][CH3:45])=[CH:40][CH:39]=3)=[C:33]([C:29]3[CH:30]=[CH:31][CH:32]=[C:27]([C:25]4[CH:26]=[C:17]([C:11]([CH3:10])([S:13]([CH3:16])(=[O:15])=[O:14])[CH3:12])[CH:18]=[C:19]5[C:24]=4[N:23]=[CH:22][CH:21]=[CH:20]5)[CH:28]=3)[N:34]=2)([OH:48])[CH3:47])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 68955407HCID 68955407, compoundHCID 178478191HCID 178478191, compound

Product 1

HCID 68957996HCID 68957996, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared according to the general procedure Cer-1 using 4-chlorophenylmagnesium bromide and methylketone from step 3. Flash chromatography (CH2Cl2:MeOH, 96:4) afforded the title compound.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0bf79d0ca1c64488989ee708b9458b4a
Source dataset
uspto-grants-2009_01
Patent number
US07482456B2

Reaction notes

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