Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | HCID 86608354 | HCID 86608354 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 57535437 | HCID 57535437 | — |
Reaction Steps
To a solution of the alphabromoketone from EXAMPLE 1, step 4 (1.0 eq) in DMF (0.1M) was added 2-aminothiazole (1.6 eq). The mixture was heated at 120° C. for 1 h, cooled, diluted with water, saturated NaHCO3 solution and EtOAc. The organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (Toluene:EtOAc, 1:3) to afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07482456B2 |
|---|
| Source dataset | uspto-grants-2009_01 |
|---|
| ORD ID | ord-fcfcb9071a534edf8f7b7ff55dc83d26 |
|---|
| Source note | uspto-grants-2009_01 |
|---|
