HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-{6-[1-Methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-{6-[1-methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}benzoate | HCID 68887704 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-{6-[1-Methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}benzoic acid | HCID 21865566 | — |
Reaction Steps
To a solution of ester from step 1 in THF (0.08M) was added LiOH (2N, 5 eq). The reaction mixture was stirred at rt for 5 h, acidified with AcOH, diluted with water and extracted with CH2Cl2. The organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated. The title compound was isolated by filtration from Hexane/ether as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482456B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-d98403e5b5d14f63961873d6ab02327e |
| Source note | uspto-grants-2009_01 |