Dichloromethane → HCID 57535420, compound

HRID 1455663Notes

Reaction equation

HRID 1455663 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[CH:15]=[C:16]([C:24]([CH3:30])([S:26]([CH3:29])(=[O:28])=[O:27])[CH3:25])[CH:17]=[C:18]3[C:23]=2[N:22]=[CH:21][CH:20]=[CH:19]3)[CH:9]=1.[C:31]([C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1)([OH:33])=[O:32].C(Cl)Cl>CO>[CH3:30][C:24]([C:16]1[CH:17]=[C:18]2[C:23](=[C:14]([C:10]3[CH:9]=[C:8]([C:3]4[C:2]([C:37]5[CH:38]=[CH:39][C:34]([C:31]([OH:33])=[O:32])=[CH:35][CH:36]=5)=[CH:7][CH:6]=[CH:5][CH:4]=4)[CH:13]=[CH:12][CH:11]=3)[CH:15]=1)[N:22]=[CH:21][CH:20]=[CH:19]2)([S:26]([CH3:29])(=[O:28])=[O:27])[CH3:25]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 3121834-Carboxyphenylboronic AcidHCID 68952902HCID 68952902, compound

Product 1

HCID 57535420HCID 57535420, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared according to the general procedure Coupling—1 using Arylbromide from step 1 and 4-carboxybenzeneboronic acid as starting materials. Flash chromatography (CH2Cl2:MeOH, 9:1) afforded the title compound.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-cd6b3ab99c45471e9ac2fca7263d11c3
Source dataset
uspto-grants-2009_01
Patent number
US07482456B2

Reaction notes

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