O-Phenylenediamine → HCID 11422096, compound

Participants

Reaction Steps

A solution of 2-bromo-2-(3-{6-[1-methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}phenyl)-1-[4-(methylsulfonyl)phenyl]ethanone from EXAMPLE 1, step 4 in DMF (0.05M) and 1,2-diaminobenzene (2 eq) was stirred at 130° C. for 18 h. The reaction mixture was cooled to rt, diluted with water and extracted with EtOAc. The organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified by flash chromatography (hexane:EtOAc, 1:1) to afforded the title compound.

Provenance & Evidence