HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyridine → 5-Chloro-N-{1,3-dioxo-2-[1-(2-pyridinyl)-4-piperidinyl]-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyridine | HCID 7973 | — |
| Reactant | 5-chloro-N-[1,3-dioxo-2-(4-piperidinyl)-2,3-dihydro-1H-isoindol-4-yl]-2-thiophenecarboxamide | HCID 12074893 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-Chloro-N-{1,3-dioxo-2-[1-(2-pyridinyl)-4-piperidinyl]-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamide | HCID 18440681 | — |
Reaction Steps
100 mg (0.257 mmol) of 5-chloro-N-[1,3-dioxo-2-(4-piperidinyl)-2,3-dihydro-1H-isoindol-4-yl]-2-thiophenecarboxamide and 0.05 ml (0.513 mmol) of 2-bromo-pyridine in 0.5 ml of pyridine are stirred at 110° C. for 48 h. The mixture is concentrated and dried under high vacuum. The product is isolated by preparative RP-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07482472B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-ac8eb2274e2c45919ef76f5f71148532 |
| Source note | uspto-grants-2009_01 |