反应详情

450 mg of Pd/C (10%) are added to a mixture of 2.1 g (5.4 mmol) of tert-butyl 4-[2-(4-nitro-1-oxo-1,3-dihydro-2H-isoindol-2-yl) ethyl]-1-piperidinecarboxylate in 25 ml of methanol. The mixture is stirred at atmospheric pressure under an atmosphere of hydrogen for 2 h and, after filtration through Celite, concentrated. The product is purified by column filtration on silica gel (dichloromethane/methanol 9:1).

1. filtrationafter filtration through Celite
2. concentrationconcentrated
3. filtrationThe product is purified by column filtration on silica gel (dichloromethane/methanol 9:1)