反应详情

温度

80 °C

NaBH4 (7.6 g; 0.2 mol) is added in small amounts to 61 g (0.2 mol) of ethyl3-(3-hexanoyl-4-methoxyphenyl)propanoate, as a solution in 500 ml of ethanol. The mixture is heated for 1 hour at 80° C. After 16 hours at room temperature, the mixture is concentrated under vacuum and poured into saturated sodium chloride solution. The resulting mixture is extracted with ether and the organic phase is dried over sodium sulfate. Evaporation of the solvents gives 58 g of product in a 94% yield.

1. concentrationthe mixture is concentrated under vacuum
2. additionpoured into saturated sodium chloride solution
3. extractionThe resulting mixture is extracted with ether
4. dry with materialthe organic phase is dried over sodium sulfate
5. customEvaporation of the solvents