Ethanol → HCID 10087256, compound

Participants

Reaction Steps

A mixture of 70 ml of ethanol, 2.7 g (0.048 mol) of potassium hydroxide, 5.9 g (0.017 mol) of ethyl4-(6-hexyl-3-oxoindan-5-yloxy)butyrate and 35 ml of water is heated for 90 minutes at the reflux point of the solvents. The solvents are evaporated off and the residue is placed in water and extracted with ether. The aqueous phase is acidified and then extracted with ether. Concentration of the solvents gives 3.6 g of product, which is purified by flash chromatography (80/20 cyclohexane/ethyl acetate): 1.5 g of crude product. Recrystallisation from hexane gives 1.3 g, m.p. 88° C., 24%.

Provenance & Evidence