Ethanol → HCID 69048864, compound

Participants

Reaction Steps

A mixture of 20 ml of ethanol, 0.975 mg (155 mmol) of potassium hydroxide, 1.2 g (35 mmol) of ethyl4-(3-methylene-6-hexylindan-5-yloxy)butyrate and 10 ml of water is heated for 5 hours at the reflux point of the solvents. The ethanol is evaporated off, the residue is taken up in water and the impurities are extracted with ether. The aqueous phase is acidified and then extracted with ether. Concentration of the solvents gives 1.1 g of product, which is purified by flash chromatography (50/50 heptane/ethyl acetate) to give a solid m.p.: 90° C. (0.8 g; 72%).

Provenance & Evidence