反应详情

154 g (0.535 mol) of ethyl3-(3-bromo-4-methoxyphenyl)propanoate are mixed with 45 g (0.8 mol) of potassium hydroxide, 600 ml of methanol and 300 ml of water. The mixture is heated at reflux for 3 hours, and the methanol is then evaporated off. The solution obtained is washed with ether; the aqueous phase is acidified and extracted with ether. The organic phase is dried (Na2SO4), and the solvents are evaporated off: white solid (132.7 g; 96%).

1. temperatureThe mixture is heated
2. temperatureat reflux for 3 hours
3. customthe methanol is then evaporated off
4. customThe solution obtained
5. washis washed with ether
6. extractionextracted with ether
7. dry with materialThe organic phase is dried (Na2SO4)
8. customthe solvents are evaporated off