Valproate → Magnesium Valproate

HRID 1455714Notes

Reaction equation

HRID 1455714 reaction equation
[C:1]([O-:10])(=[O:9])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].O.[C:12]([O-:21])(=[O:20])[CH:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16].[Mg+2:22].C([O-])(=O)C(CCC)CCC>O>[C:1]([O-:10])(=[O:9])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].[Mg+2:22].[C:12]([O-:21])(=[O:20])[CH:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 3549980ValproateHCID 71439018Magnesium;bis(2-propylpentanoate);hydrate

Product 1

HCID 147515Magnesium Valproate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Surprisingly, the inventors have discovered that a heretofore unknown valproate salt, magnesium valproate hydrate, a white solid having the molecular formula C16H30O4Mg.x H2O, is recovered in high yields from an alcoholic solution of magnesium valproate by adding a polar, non-oxygen-containing organic solvent having a boiling point of about 130° C. or lower in a volume sufficient to reduce the solubility of the magnesium valproate in the resulting reaction mixture to less than about 0.01 g/mL. The polar, non-oxygen-containing organic solvent is acetonitrile, propionitrile, butyronitrile, or isobutyronitrile. Acetonitrile is most preferred.

Workup

  1. customis recovered

Sources & evidence

ORD record
ord-6aaabd3d5f824156baa1b3cd9b66066c
Source dataset
uspto-grants-2009_01
Patent number
US07482486B2

Reaction notes

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