Ethyl Acetate → Salbutamol

Participants

Reaction Steps

In a 2 L reactor equipped with a condenser, thermometer, and mechanical stirrer at 20° C. and under nitrogen, a suspension of wet levalbuterol hydrochloride (97.6 g), ethylacetate (440 mL) and methanol (49 mL) was formed. The suspension was stirred at 22° C.±2° C. for 4 hours. The solid was collected by filtration and washed with an ethylacetate:methanol mixture (90:10, 97 mL), and ethylacetate (2×97 mL). The product was dried at 22° C.±2° C. under vacuum (res. press. 40-45 mm Hg) for 24 hours to obtain 64.0 g (dry weight) in 92.5% yield from pure (R)-SLB.D-DBTA. The overall yield from racemic salbutamol to pure levalbuterol hydrochloride: 39.5%.

Provenance & Evidence