Hydrochloric Acid → HCID 57531451, compound

Participants

Reaction Conditions

Reaction Steps

To a flask containing [2-(2,6-diethyl-phenyl)-4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-6-methyl-pyrimidin-5-ylmethyl]-methyl-(1S)-(1,2,3,4-tetrahydro-naphthalen-1-yl)amine (80 mg, 0.148 mmol) is added HCl (3 M, 20 mL) and the reaction is heated at 60° C. for 4 h. Once cool, the reaction is basified with NaOH (1 N, 100 mL)) and EtOAc (100 mL) is added to extract the product. The organic layer is washed with water (100 mL), brine (100 mL) and dried over Na2SO4. Filtration, concentration and vacuum drying yields the title compound as a colorless gum. [mass expected (496.69); mass found (496.32)].

Provenance & Evidence