Potassium Carbonate → HCID 57531550, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-2-(2,6-diethylphenyl)-5-((5-isopropyl-2-methylphenoxy)methyl)-6-methylpyrimidine (423 mg, 1 mmol) and tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (Wustrow and Wise, Synthesis, 1991, 993) (371 mg, 1.2 mmol) in anhydrous DMF (5 mL) is added K2CO3 (414 mg, 3 mmol). The mixture is bubbled with N2 for 15 min and PdCl2dppf (28 mg) is added. The mixture is then heated under N2 at 80° C. for 16 h. After cooling to room temperature, the mixture is diluted with ether, washed with water and brine. The organic layer is dried over anhydrous MgSO4, concentrated and purified by silica gel column chromatography to provide the title product. [mass expected (569.8); mass found (M+1: 570.6)].

Provenance & Evidence