(S)-N-Benzyl-2-(Boc-amino)-2-phenylacetamide → (S)-2-Amino-N-benzyl-2-phenyl-acetamide hydrochloride

HRID 1455826Notes

Reaction equation

HRID 1455826 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:15](=[O:24])[NH:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(C)(C)C.[ClH:26].O1CCOCC1>>[ClH:26].[NH2:7][C@@H:8]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:15]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:24]

Participants

3

Reactant 2

HCID 12148799(S)-N-Benzyl-2-(Boc-amino)-2-phenylacetamideHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 68955044(S)-2-Amino-N-benzyl-2-phenyl-acetamide hydrochloride

Procedure

(S)-(Benzylcarbamoyl-phenyl-methyl)carbamic acid tert-butyl ester (0.85 g, 2.50 mmol) was dissolved in HCl/dioxane (10 mL, 4.0M). The mixture was stirred at room temperature overnight. The volatiles were removed under reduced pressure to provide the desired product in quantitative yield.

Workup

  1. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-6ee7254bd0c14aab8836a77edcd90d5c
Source dataset
uspto-grants-2009_01
Patent number
US07482368B2

Reaction notes

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