Sodium Bicarbonate → HCID 22262741, compound

Participants

Reaction Steps

The product from step (b) (407.5 mg, 0.892 mmol), (S)-N-ethyl-2-phenylglycinamide hydrochloride salt (316.3 mg, 1.47 mmol) and acetic acid (10 drops) were suspended in CH2Cl2 (25 mL), and the reaction mixture was stirred at room temperature for 20 min. NaB(OAc)3H (2.1 eq) was then added, and the reaction mixture was stirred at 50° C. for 5.5 h. Saturated NaHCO3 (8 mL) and CHCl3 (12 mL) were then added, and the organic layer was washed with water (6 mL), and then concentrated in vacuo. The product was purified by flash chromatography using 30:70 of hexane:EtOAc to afford 441.4 mg of the title compound.

Provenance & Evidence