HCID 22105408, compound → HCID 22105402, compound

Participants

Reaction Steps

To a solution of 20(100 mg, 0.33 mmol) in ethanol (15 mL) was added MnO2 (0.5 g) and the reaction mixture was stirred for 4 h at room temperature. The reaction mixture was filtered through celite and the solid was washed with ethanol. Solvent was removed in vacuo and a grey solid 21 was obtained (54 mg, 54% yield). An analytical sample was recrystallized in ethyl acetate. mp: 253° C. (dec). 1H NMR (DMSO-d6, ppm): 10.60 (brs, 1 H, NH), 9.85, (s, 1 H, NH), 8.26 (s, 1 H, CHO), 7.84-7.35 (m, 9 H, Ar--H). Anal. (C18H12N2O3 0.3H2O), C, H, N.

Provenance & Evidence