Benzyl Chloride → 1-(Benzyloxy)-3-bromobenzene

Participants

Reaction Steps

A slurry of 3-bromophenol 100 g (580 mmol), benzylchloride 80 g (700 mmol), and K2CO3 168 g (1210 mmol) in 2 L of DMF was stirred for sixteen hour at ambient temperature. The reaction mixture was filtered and evaporated to dryness. The solid was partioned between CHCl3 and water. The organic layer was separated, washed twice with brine, and dried by filtration through anhydrous Na2SO4. The solution was evaporated to dryness. This yielded 142.5 g of the title compound as a white solid.

Provenance & Evidence