Methanol → HCID 22105622, compound

Participants

Reaction Steps

n-Butyl 6-[N-(1-(2-benzyloxy-5-bromophenyl)-eth-1-yl)-N-ethylamino]pyridazine-3-carboxylate (180mg) was dissolved in THF (5 mL) and methanol (5 mL) and sodium hydroxide solution added (0.61 mL, 2M). The mixture was stirred for one hour at ambient temperature, and then the solvents evaporated off. The resulting foam was dissolved in water (20 mL) and pH adjusted to pH 4-5 with glacial acetic acid. A white precipitate formed which was filtered off, washed with water and dried for 17 hours at 5° C. to give 6-[N-(1-(2-benzyloxy-5-bromophenyl)eth-1-yl)-N-ethylamino]pyridazine-3-carboxylic acid (134 mg, mp 129.2° C.).

Provenance & Evidence