反应详情

A solution of methyl 2-[N-(2-(2-thienylmethoxy)-5-bromobenzyl)-N-ethylamino]pyridine-5-carboxylate (0.53 g, 1.15 mmol) in methanol (25 mL) was treated with aqueous sodium hydroxide (2N, 5 mL). The reaction was heated to reflux for 9 hours. The reaction mixture was cooled and evaporated and residue was diluted with water and acidified with acetic acid. The off-white solid was filtered off to give 2-[N-(2-(2-thienylmethoxy)-5-bromobenzyl)-N-ethylamino]pyridine-5-carboxylic acid (0.41 g, 91%).

1. temperatureThe reaction was heated
2. temperatureto reflux for 9 hours
3. temperatureThe reaction mixture was cooled
4. customevaporated
5. additionresidue was diluted with water
6. filtrationThe off-white solid was filtered off