Formic Acid → HCID 22105511, compound

Participants

Reaction Steps

A mixture of methyl-2-[N-(2-benzyloxy-5-nitrobenzyl)-N-t-butoxycarbonylamino]pyridine-5-carboxylate (5.2 g) and formic acid (20 ml) was heated on a steam bath to give a clear solution. The mixture was evaporated to dryness and the residue obtained was dissolved in diethylether (100 ml) and washed with saturated sodium bicarbonate. The organic layer was dried and evaporated to give methyl-2-[N-(2-benzyloxy-5-nitrobenzyl)-amino]pyridine-5-carboxylate, yield 3.3 g. This same procedure was used to prepare ethyl-2-[N-(2-benzyloxy-5-bromobenzyl)-amino]thiophene-5-carboxylate.

Provenance & Evidence