HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 6-[2-benzyloxy-5-bromobenzylamino]-3-pyridazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl 6-[N-(2-benzyloxy-5-bromobenzyl)-N-(tert-butoxycarbonyl)amino]-3-pyridazinecarboxylate | HCID 22105523 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 6-[2-benzyloxy-5-bromobenzylamino]-3-pyridazinecarboxylate | HCID 22105509 | 92% |
Reaction Steps
A mixture of ethyl 6-[N-(2-benzyloxy-5-bromobenzyl)-N-(tert-butoxycarbonyl)amino]-3-pyridazinecarboxylate (2.0 g) and trifluoroacetic acid (25 ml) in CH2Cl2 (25 ml) was allowed to stand for 18 hours. The solvents were evaporated, the residue dissolved in CH2Cl2 and washed with dilute aqueous Na2CO3 solution, dried (MgSO4) and evaporated to give ethyl 6-[2-benzyloxy-5-bromobenzylamino]-3-pyridazinecarboxylate as a solid (1.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05843942 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-39b2d114c0544e7c992378c21d71dde2 |
| Source note | uspto-grants-1998_12 |