Water → HCID 22105874, compound

HRID 1456003Notes

Reaction equation

HRID 1456003 reaction equation
C1C(=O)N([Br:8])C(=O)C1.[CH2:9]([C:13]1[CH:18]=[C:17]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)[N:16]2[N:27]=[CH:28][CH:29]=[C:15]2[N:14]=1)[CH2:10][CH2:11][CH3:12].O>COCCOC.O>[Br:8][C:29]1[CH:28]=[N:27][N:16]2[C:17]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)=[CH:18][C:13]([CH2:9][CH2:10][CH2:11][CH3:12])=[N:14][C:15]=12

Participants

5

Reactant 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 9882212HCID 9882212, compound

Product 1

HCID 22105874HCID 22105874, compoundYield 93.8%

Reagents, catalysts & solvents 1

HCID 18180031Water 1,2-dimethoxyethaneSolvent

Procedure

NBS (0.38 g) was added to a solution of 0.5 g of 5-n-butyl-7-(4-pyridylmethoxy)pyrazolo[1,5-a]pyrimidine in 10 ml of DME-water (3:1) at 0° C. and stirred for 1 hour. The mixture was stirred at room temperature for another 2 hours to allow the reaction to proceed. Some water was added to the reaction mixture, and the crystals precipitated were collected by filtration to provide 0.6 g of the title compound as colorless crystals. The structure and melting point of the compound obtained are shown in Table 1.

Workup

  1. stirringThe mixture was stirred at room temperature for another 2 hours
  2. customthe reaction
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-8f3e9f373ac04791ba385a4764671db9
Source dataset
uspto-grants-1998_12
Patent number
US05843951

Reaction notes

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