Sodium Azide → HCID 22106551, compound

Participants

Reaction Steps

4-Benzyloxy-3-fluoro-phenylamine as a solution in acetic acid (50 ml) was heated to 75° under nitrogen. Triethylorthoacetate (10.3 ml) was added. After a further 45 min at this temperature, sodium azide (7.8 g) was added portionwise. Heating was continued for a further 3 h, the reaction cooled overnight and poured into sodium bicarbonate solution (8%, ca. 500 ml), extracted with dichloromethane (3×100 ml), dried (Na2SO4) and evaporated. The residue was purified by FCC with (dichloromethane/methanol (995:5)) to give the title compound as a solid (4.6 g).

Provenance & Evidence