4,5-Dimethylthiazole → HCID 22106686, compound

HRID 1456336Notes

Reaction equation

HRID 1456336 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[CH3:8][C:9]1[N:10]=[C:11]([C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[S:12][C:13]=1[CH3:14]>CS(C)=O>[CH3:1][C:2]1[N:3]=[C:4]([C:15]([C:11]2[S:12][C:13]([CH3:14])=[C:9]([CH3:8])[N:10]=2)([OH:20])[C:16]([F:19])([F:18])[F:17])[S:5][C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 625104,5-DimethylthiazoleHCID 221066891-(4,5-Dimethyl-1,3-thiazol-2-yl)-2,2,2-trifluoroethan-1-one

Product 1

HCID 22106686HCID 22106686, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

From 4,5-dimethylthiazole and 4,5-dimethyl-2-trifluoroacetylthiazole. M.p. 122°-123.5° C. 13C Nmr (d6 -DMSO) 10.5, 14.4, 76.9 (g, J 30 Hz) 123.1 (q, J 286Hz), 129.0, 147.9 and 161.0 ppm.

Sources & evidence

ORD record
ord-65e2b03efe5c43f88b3bb409e6723781
Source dataset
uspto-grants-1998_12
Patent number
US05843971

Reaction notes

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