HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 22915156, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | HCID 22106673 | HCID 22106673 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 22915156 | HCID 22915156 | — |
Reaction Steps
1-(2,4-Dimethyl-5-thiazolyl)-1-(2-thiazolyl)ethanol (200 mg) was suspended in benzene (2 ml) at room temperature. Diphenylphosphoryl azide (212 μl) was added, followed by 1,8-diazabicyclo[5,4,0]undec-7-ene (152 μl). The mixture was stirred at ambient temperature for 72 hours and was then diluted with ethyl acetate and water. Work-up in the usual fashion including flash chromatography then gave the title compound. 13C Nmr (CDCl3) 16.4, 18.9, 28.4, 64.9, 120.3, 132.4, 143.0, 149.4, 163.3 and 172.3 ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05843971 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-53a2fdef394f4455b68fac63daf06c1b |
| Source note | uspto-grants-1998_12 |