Ethyl Acetate → HCID 178453494, compound

Participants

Reaction Steps

In 10 ml of dry tetrahydrofuran was dissolved 1.05 g of N-t-butoxycarbonyl-2-(trans-4-t-butyldimethylsilyloxymethylcyclohexyl)ethylamine, and 8.48 ml of tetrabutylammonium fluoride (1.0M tetrahydrofuran solution) were added dropwise thereto with stirring under ice-cooling, and the resulting mixture was stirred at room temperature overnight. To the reaction mixture were added 150 ml of ethyl acetate, and the mixture was washed with an aqueous sodium bicarbonate solution and an aqueous sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography employing cyclohexane-ethyl acetate (2:1) as an eluting solvent to obtain 471 mg of the desired compound as a colorless crystalline solid.

Provenance & Evidence