Trifluoromethanesulfonic anhydride → HCID 86753393, compound

Participants

Reaction Steps

8.4 ml (0.050 mol) of trifluoromethanesulphonic anhydride are added at 0° C. over 10 minutes to a solution of 11 g (0.042 mol) of (R)-5-(methoxymethyl)-3-(6-hydroxy-1,2-benzisoxazol-3-yl)oxazolidine-2-one in 110 ml of pyridine. The solution is stirred for 18 hours and then poured into ice-cold 2N aqueous hydrochloric acid solution. The product is extracted with ethyl acetate and then the organic phase is dried over sodium sulphate and concentrated under reduced pressure. 16.5 g of product are obtained.

Provenance & Evidence